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Activation of GLP-1 receptors leads to: Increased insulin secretion in response to glucose Slowed gastric emptying , helping regulate blood sugar Reduced appetite and food intake , promoting weight loss By targeting only the GLP-1 receptor, Semaglutide produces effective weight loss and metabolic control, but with a ceiling effect that limits its full potential

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Another compound, altenusin, blocks EMT in tubular epithelial cells, thereby reducing abnormal ECM accumulation and contributing to fibrosis prevention (124, 125)

10.1016/j.tips.2008.05.001 Trends Pharmacol Sci

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